Development of micro and nanoresonators for Nuclear Magnetic Resonance Spectrometry

Reference Presenter Authors
Joao Paulo Sinnecker Sinnecker, J.P.(Centro Brasileiro de Pesquisas Físicas); Sampaio, L.(Centro Brasileiro de Pesquisas Físicas); Loreto, R.(Centro Brasileiro de Pesquisas Físicas); Consalter, D.M.(Fine Instrument Technology); Oliveira, I.(Centro Brasileiro de Pesquisas Físicas); Martins, A.(Centro Brasileiro de Pesquisas Físicas); Sarthour, R.(Centro Brasileiro de Pesquisas Físicas); Silva, J.(Centro Brasileiro de Pesquisas Físicas); Nuclear Magnetic Resonance (NMR) is increasingly used in many technological applications and is responsible for significant advances in medicine, chemistry, physics, and biology. One of the most critical aspects of NMR equipment is the probe (or sensor) responsible for detecting the NMR signal. For a better signal-to-noise ratio, there is an ideal relationship between the relative size of the sensor and the sample to be analyzed. Therefore, micro or nanoscopic scale samples require sensors of the same scale. FIT - Fine Instrument Technology recently completed the development of a SpecFIT Ultra (NMR) spectrometer through FINEP funding in technological cooperation with the CIERMag (Magnetic Resonance Imaging and Imaging Center) group CIERMag. São Carlos Physics, USP. SpecFIT Ultra is responsible for controlling the sensors of NMR equipment. The present work will show the development of sensors that allow the detection of NMR signals from very small volumes. The reduction in size brings with it another vital aspect for NMR, which favors the homogenization of the magnetic field felt by the sample, which makes the resonance lines better resolved, increasing the resolution of the measurements, and allows the identification of different substances. Micrometer prototype sensors were fabricated using optical lithography as well as laser micromachining. The sensor is designed to operate at a magnetic field magnetic of approximately 0.5 T, and a frequency of around 20 MHz, as well as in the 12 T, 500 MHz range. The final probes will be versatile and can be used in the academic field, the pharmaceutical and healthcare industry, mining fieldwork, among many possible applications. Such versatility will provide better product insertion in different markets. Such equipment still does not exist in the market and has a high degree of technological innovation. This is a joint collaboration of the Centro Brasileiro de Pesquisas Físicas and FIT. The authors would like to acknowledge the financial support of the SibratecNANO.
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