Green Nanotechnology’s Connectivity to “Nano-Ayurvedic Medicine”—An Immunomodulatory Holistic Medicine Approach for Cancer Therapy—Pre-Clinical and Human Clinical Investigations

Reference Presenter Authors
(Institution)
Abstract
01-181
Kattesh V. Katti Katti, K.V.(Institute of Green Nanotechnology); It is becoming increasingly clear that various chemotherapeutic, immunotherapeutic and radiation-based treatment modalities activate NF-?B transcription factors, which are responsible for triggering various pro-tumorigenic cascade of processes within the tumor microenvironment. Tumor progression and the evasion of systemic immune surveillance are all dictated by significantly high levels of various immunosuppressive factors, such as IL-10, IL-6, and TGF-?. Most cancer drugs, in current use which belong to specific targeted or cytotoxic agents, rely on “one gene, one target, one disease” approach despite the fact that cancer is a very complicated multi-target and multi-gene defective disease. However, several examples of phytochemical-based therapeutic approaches have shown the power of cocktail of phytochemicals in traditional Indian Ayurvedic (Chinese and African) medicines to be multi targeted by enhancing the CD4+/CD8+ T cell ratio in the tumor microenvironment. Herbal-based Ayurvedic medicine are also known to reeducate the macrophage by promoting the M1 differentiation of TAM, suggesting the poly-pharmacological and poly-targeted nature of phyto agents. This lecture will discuss both in vitro and in vivo pre-clinical investigations including results from recent human clinical trials in metastatic breast tumor patients. This lecture will highlight the application of innovative Green Nanotechnology discoveries, made in Dr. Katti’s laboratory, to develop novel nanomedicine agents derived from combination of tumor specific phytochemicals encapsulated onto biocompatible gold nanoparticles. The longstanding objective of this approach focuses on providing credible scientific rationale to phytochemical-based herbal (Ayurvedic) medicine—all aimed at developing new Precision Medicine modality referred to as ‘Nano-Ayurvedic Medicine. Green Nanotechnology also allows the development of reproducible formulations of herbal and classical Ayurvedic medicines thus providing a pathway for clinical trials for internal/external validity, to allow the safety and efficacy of specific herbal medicines in a more accurate and scientifically verifiable way. This lecture will discuss details on how green nanotechnology can be used to develop small-molecule phytochemical(s)-functionalized gold nanoparticles to simultaneously achieve: (i) Inhibition of NfkB activation; (ii) Targeting TAM; and (iii) Inhibition of TNF-? induced p65 phosphorylation; and concomitant immunomodulatory therapeutic action. Details on the new invention of a medical modality, referred to as ‘Nano-Ayurvedic Medicine’, recently approved by the US Patents and Trade Marks Office will be presented. The lecture will also highlight the importance of clinical translation in medical research through recent results from human clinical trials on cancer patients of Nano-Ayurvedic Nanomedicine drugs derived through green nanotechnology.
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