Advances in Nanomedicine: Theranostic Nanomaterials for Cancer therapy and Nanotoxicology Studies

Reference Presenter Authors
Valtencir Zucolotto Zucolotto, V.(University of Sao Paulo); Nanomaterials are capable of targeting specific tissues and cells, promoting diagnosis and therapy at the same time. These so-called theranostic materials represent the state-of-the-art in the use of nanocomposites for cancer diagnosis and treatment. Due to their ease of preparation and functionalization, graphene oxides and gold nanorods (AuNRs), in particular, have found applications as theranostic agents for cancer therapy. These materials exhibit an absorption band in the near infrared region - where the maximum radiation penetration through tissues occurs-, which makes them appropriate for in vivo photothermal applications. This talk will address the synthesis and application of a hybrid nanocomposite based upon AuNRs coated with human lung adenocarcinoma epithelial cell (A549) membrane, used as active materials in photohyperthermia against cancer cells. Graphene oxide nanocomplexes were also synthesized and applied in the hyperthermia studies. Upon infrared irradiation, the nanoconjugates presented higher toxicity to cancer cells. The incorporation of gold nanorods into real membrane monolayers was also studied using Langmuir techniques. Our results revealed significant differences on how the nanorods systems interact with the membranes. The use of cancer cell membrane-coated nanoparticles opens up new possibilities regarding the development of efficient theranostic nanosystems and brings benefits to the field of personalized medicines. The toxicity exhibited by the nanocomplexes against healthy human cells and aquatic organisms will also be addressed.
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