Nanohybrid colloids prepared using polyelectrolyte-modified soft and hard templates for environmental and biomedical applications

Reference Presenter Authors
Geoffrey Bothun Bothun, G.(University of Rhode Island); Abbasi, A.(University of Rhode Island); Anik, M.(University of Rhode Island); Pan, A.(University of Rhode Island); Jakaria, M.(University of Rhode Island); Meenach, S.(University of Rhode Island); Bose, A.(University of Rhode Island); One of the goals in our group is to create and utilize versatile templating techniques to design nanohybrid colloids that address emerging environmental and biomedical needs. A simple way to modify the surface properties of a soft or hard material is through polyelectrolyte deposition. This process, driven by enthalpic and entropic interactions, creates a surface layer that reflects the charge density of the polyelectrolyte as well as the molecular mobility of the polymer chains. We have demonstrated this using polyelectrolyte deposition to modify liposomes (soft) and fractal carbon black nanoparticles (hard) in order to create templates that guide the synthesis of gold nanoshells. By tuning the surface properties and synthesis conditions, a variety of heterogeneous gold nanoshell structures can be generated from discontinuous to “spiky” with distinct optical properties. For example, when templating with liposomes, which are soft nanoscale capsules with internal aqueous reservoirs, multifunctional colloids are created containing encapsulated iron oxide nanoparticles that can be activated thermally using near-infrared and alternating current electromagnetic fields. With these active triggers, it is possible to control drug release and thermal treatment (hyperthermia) in cell cultures through external stimuli. When templating with fractal carbon black particles, colloidal structures are created that are capable of capturing environmental pollutants and detecting them in situ using surface enhanced Raman spectroscopy (SERS). This presentation will describe the development of this templating approach and work underway using a new soft template, protein nanoparticles, to create gold nanosensors that can detect intracellular levels of reactive oxygen species.
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