Magnetic Nanoparticles for Biosensing

Reference Presenter Authors
T Randall Lee Lee, T.(University of Houston); Magnetic nanoparticles (MNPs) are widely used in a plethora of biomedical applications that includes biosensing, bioimaging, hyperthermia, and drug delivery. Given that biosensors provide both qualitative and quantitative information regarding the composition of the molecules in which the sensor is situated, biosensing applications require specific properties that strongly depend on the size, shape, functionality, stability, and magnetization of the MNPs. Our research efforts in this area include the use of judiciously chosen reaction parameters (e.g., solvents, surfactants, and temperatures) to control the size and shape of the resultant particles. Preliminary considerations led us to examine the design, synthesis, and study of cubic magnetic nanoparticles for single-molecule biosensing. While developing this application, we discovered that cubic nanoparticles exhibit greater magnetic properties (on both mass:mass and volume:volume bases) than the more commonly studied and widely used spherical nanoparticles. Moreover, larger magnetic nanoparticles offer greater sensing utility than smaller magnetic nanoparticles. These findings, along with their underpinnings and implications, will be presented and discussed.
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